The team, which includes Steven Stice and Franklin West in the College of Agricultural and Environmental Sciences and Claudio Afonso at the Southeast Poultry Research Laboratory of the U.S. Department of Agriculture’s Agricultural Research Service, used a technology platform called shRNA — single strands of RNA that fold back on themselves — to selectively stop the production of nucleic acids that cause disease, such as the Newcastle disease virus. “We’ve taken many years to prove that this technology is viable,” he continued, “and we’re now ready to expand our work to the next stage.” The research team’s tooling process for enhancing disease resistance, published recently in the Journal of the International Alliance for Biological Standardization, is potentially a much better way of disease protection than vaccination because it introduces permanent genetic resistance, which is transmittable to a bird’s offspring, the researchers said. In contrast, many vaccines provide protection for a given period of time and must be re-administered periodically. Shipping disease-resistant chickens produced here in the U.S. could be the best possible solution for many countries, Stice said. “Ultimately, you could have birds that are both avian influenza resistant and Newcastle disease virus resistant,” said West, an assistant professor in the animal and dairy science department. “Theoretically, you may never have to vaccinate again.” “With this technology, we can target specific regions used by the Newcastle disease virus that are critical for its survival,” said Stice, a Georgia Research Alliance Eminent Scholar and director of the Regenerative Bioscience Center. “Preventing these lethal viruses from replicating in individual chickens may in the end reduce the overall level of virus transmission from one chicken to the next.” Organized distribution of vaccine products can also present problems, especially in countries where farmers may not have a refrigerator or other means to store the vaccines at the temperature needed to keep the vaccine alive. This is particularly true in rural areas where backyard flocks may be a farmer’s main source of income. Newcastle disease is a worldwide problem and is caused by one of the most deadly of all viruses that spreads between birds. Exotic Newcastle virus, the most devastating form of the virus, has been eradicated in the U.S. and Canada. The milder forms of Newcastle are kept under control using vaccines. Multiple types of animals and diseases could be targeted. This technology could also be applied to avian influenza and swine flu. The study, “Delayed Newcastle disease virus replication using RNA interference to target the nucleoprotein,” is available at sciencedirect.com/science/article/pii/S1045105615000275. The Regenerative Bioscience Center at the University of Georgia links researchers and resources, collaborating in a wide range of disciplines to develop new cures for the devastating diseases. With its potential restorative powers, regenerative medicine could offer new ways of treating diseases for which there are currently no treatments—including heart disease, Parkinson’s, Alzheimer’s and stroke. The RBC is geared toward identifying regenerative solutions for numerous medical conditions that affect both animals and people. For more information, see www.rbc.uga.edu. Poultry disease is an international issue, especially when there is an outbreak close to home. However, it’s a particularly costly problem in developing countries. Developing animals to be resistant to disease may be one of the long-term solutions. University of Georgia researchers in the Regenerative Bioscience Center have spent the last four years gathering data that could make the process a reality.
Published on October 19, 2017 at 12:34 am Contact Myelle: [email protected] Within seconds of Eric Dungey taking the final knee to seal Syracuse’s upset of No. 2 Clemson on Friday night, some of the 42,475 fans in attendance made the field a sea of orange. The Carrier Dome staff is equipped to handle such stormings with stairs provided for fans to carefully exit onto the field. But often it’s too little, too late.Once the first fan rushes the field, more follow suit. That night, most fans jumped a steep 5 feet from the stands to access the field.Six individuals sought medical attention at the Dome, said Pete Sala, vice president and chief facilities officer and Carrier Dome managing director. Two individuals were rushed to Upstate Medical University’s ER with a broken ankle and wrist, an Upstate spokesman said.“It was pretty crazy,” field utility volunteer and junior Television-Radio-Film and Political Science dual major J.D. Killough said. “Police congregated around us when they started realizing fans may rush the field.”About 30 minutes after the victory, Killough saw a man in his mid-to-late 20s sitting to the side on a bench, pants rolled up, leg exposed, swollen and seemingly broken. When Emergency Medical Service arrived to assist, Killough remembered the man was in shock and seemed not to realize the damage done to his leg.AdvertisementThis is placeholder textOne injured fan started a GoFundMe to offset medical bills after jumping a railing to rush the turf. On impact, the fundraising page detailed, someone pushed him from behind. The landing crushed his right ankle, displaced his right kneecap, broke both his legs and required two surgeries that included rods, plates and pins. The fan, the post read, will miss three to six months of work.In three days, 70 people donated $3,653 of a $4,400 goal.“Our chief priority is the safety and security of our student-athletes, the officials and our fans,” SU said in a statement. “Consistent with our Division 1 peers, we recognize we cannot always prevent fans from going onto the field. Jumping over rails inherently puts fans at risk, which is why our Fan Code of Conduct asks our fans to celebrate in a respectful and responsible fashion.”Killough saw another woman, whom he estimated to be between 55-to-65 years-of-age, injured. In the midst of the mayhem, he said, she had held onto the railings as people stormed by until she flipped over the railing.“People just weren’t paying attention,” Killough said. “Chaos is good, but you have to be a little more careful.” Comments Facebook Twitter Google+